Batch-controlled raw materials validated by HPLC/UV assays with comprehensive COA and full batch traceability for international export.
Silybin (CAS Number: 22888-70-6, Molecular Formula: C₂₅H₂₂O₁₀) represents the most biologically active, major flavonolignan component isolated from silymarin, the standardized extract of milk thistle seeds (Silybum marianum). While commercial silymarin extracts consist of a complex mixture of flavonolignans including silybin, isosilybin, silychristin, and silydianin, pure Silybin powder is isolated as a mixture of two diastereomers: Silybin A and Silybin B in an approximate 1:1 equimolar ratio. Modern pharmacological research confirms that Silybin is responsible for up to 70% to 80% of silymarin's total therapeutic and hepatoprotective capacity.
As a leading Chinese botanical extraction factory, RAAG Biotech Co., Ltd. supplies high-purity Silybin powder (assaying up to 98% by HPLC) to pharmaceutical compounders, veterinary nutrition formulators, and dietary supplement brands across Uruguay. Our specialized isolation processes overcome the native physical limitations of raw silymarin—specifically its poor water solubility, low oral bioavailability, and inconsistent diastereomeric ratios—enabling precision formulations for human and animal health.
Formulators evaluating raw materials require complete clarity on assay methodology, marker identification, and solvent residue thresholds. Standard UV-Vis spectrophotometry often overestimates silymarin content due to non-specific light absorption by oxidized polyphenols. RAAG Biotech utilizes high-performance liquid chromatography (HPLC) paired with photodiode array detection (PDA) to separate and quantify individual flavonolignan peaks according to USP and European Pharmacopoeia (EP) monographs.
| Analytical Parameter | Standard Silymarin 80% (UV) | High-Purity Silybin Powder 98% (HPLC) | Silybin Phospholipid Complex |
|---|---|---|---|
| Primary Marker Compound | Mixed Flavonolignans | Silybin A + Silybin B ≥ 98.0% | Silybin-Phosphatidylcholine (1:2 ratio) |
| Physical Appearance | Light Yellowish Powder | Fine Off-White to Light Yellow Powder | Yellowish-Brown Granular / Powder |
| Aqueous Solubility | < 50 µg/mL (Practically Insoluble) | Hydrophobic (Requires Lipid Carrier) | Dispersible / Enhanced Micellar Solubilization |
| Relative Bioavailability | 1x Baseline | 2.5x Baseline (Unbound Monomer) | 4.5x - 10x Baseline Absorption |
| Residual Solvent Limits | Ethanol < 5000 ppm / Acetone < 5000 ppm | Ethanol < 3000 ppm (Class 3) | Solvent-Free CO₂ / Organic Ethanol System |
| Heavy Metal Control | Pb < 3.0ppm, As < 1.0ppm, Cd < 1.0ppm, Hg < 0.1ppm | Strict USP <232>/<233> Compliance | Strict Ultra-Pure Grade Control |
By employing ethanol reflux extraction followed by targeted crystallization and column chromatographic fractionation, our production facilities eliminate unwanted plant resins, chlorophyll, and heavy lipophilic impurities, delivering a crystalline monomeric powder with exceptional batch-to-batch consistency.
Tailored raw material solutions aligned with Uruguay's agricultural strength, veterinary requirements, and expanding pharmaceutical hubs.
Uruguay is a global powerhouse in cattle, sheep, and equine husbandry. High-yielding dairy cattle in San José and Colonia, as well as beef herds in Tacuarembó, frequently encounter metabolic stress, mycotoxin contamination (endophytic alkaloids in pastures), and hepatic lipidosis during the transition period. Silybin acts as a potent free radical scavenger, stabilizing hepatocytes, enhancing protein synthesis through RNA polymerase I stimulation, and regulating biliary lipid secretion. Veterinary drug manufacturers in Montevideo utilize our bulk Silybin powder to formulate oral drenches, boluses, and feed additives for livestock and high-value polo horses.
With consumer awareness rising regarding non-alcoholic fatty liver disease (NAFLD/MASLD), lifestyle wellness, and metabolic syndrome across Uruguay's urban centers, local nutraceutical brands are upgrading from crude silymarin to high-absorption Silybin formulas. Formulators integrate Silybin with lecithin (phytosome technology), choline, or alpha-lipoic acid into hard gelatin capsules, tablets, and effervescent stick packs. Silybin inhibits NF-κB inflammatory cascades, downregulates TGF-β1 mediated hepatic stellate cell activation, and guards membrane lipids against oxidative degradation.
Uruguay experiences high solar UV radiation during summer months along its coastal zones (Punta del Este, Maldonado). Cosmetic chemists leverage Silybin’s potent UV-B shielding, ROS neutralization, and matrix metalloproteinase (MMP) inhibitory properties. Incorporated into anti-aging creams, repair serums, and post-sun lotions, Silybin mitigates sunburn cell formation, prevents collagen breakdown, and calms cutaneous inflammatory responses triggered by environmental oxidative stressors.
Uruguay stands out in South America for its regulatory stability, strong financial framework, and stringent health standards. The procurement of active botanical ingredients (APIs and nutraceutical raw materials) is governed by key authorities including the Ministerio de Salud Pública (MSP) for human health products and the Ministerio de Ganadería, Agricultura y Pesca (MGAP) for veterinary inputs.
When Uruguayan importers bring bulk plant extracts into Montevideo or operate via free trade zones such as Zonamerica or Parque de las Ciencias, they require audit-ready technical files. Standard compliance demands include:
Bulk Silybin powder exported to Uruguay typically falls under NCM / HS Code 2932.99.90 (Heterocyclic compounds with oxygen hetero-atom(s) only) or HS Code 1302.19.99 (Vegetable saps and extracts). Imports destined for local manufacturing inside Uruguay benefit from streamlined customs processing when accompanied by valid Certificate of Origin documentation, reducing tariff frictions within regional trade frameworks.
RAAG Biotech maintains robust export channels to Uruguay. Air freight shipments arrive directly at Carrasco International Airport (MVD) within 5 to 7 business days, while bulk sea freight containers land at the Port of Montevideo. All goods are packed in double-layer polyethylene inner bags sealed inside fiber drums (25 kg net weight) to withstand oceanic transit humidity and prevent oxidation.
A direct primary manufacturer equipped with advanced extraction lines, full batch traceability, and audit-ready quality systems.
Operating dedicated production facilities since 2014, RAAG Biotech is a direct producer—not a broker. We control raw material sourcing from contracted milk thistle planting bases to guarantee uniform seed silybin content.
Equipped with Supercritical CO₂ fluid extraction, low-temperature vacuum concentration, membrane purification, and dynamic column chromatography. We isolate delicate active monomers without chemical degradation.
Our GMP-audited facilities follow stringent ISO9001 and HACCP quality management systems. Every production batch is delivered with complete documentation, MSDS, Allergen Statements, and COA.
We engineer customized particle sizes (60 to 120 mesh), specialized carriers (maltodextrin, rice starch, sunflower lecithin), and water-soluble liposomal complexes for bespoke client requirements.
Silymarin 80% is a total extract containing a mixture of flavonolignans (Silybin A/B, Isosilybin A/B, Silychristin, Silydianin) and plant fats. Silybin Powder 98% is an isolated monomeric fraction containing exclusively Silybin A & B isomers. Silybin exhibits significantly higher specific biological activity, lower required clinical dosage, and cleaner integration into complex pharmaceutical or liposomal formulations.
Every shipment is accompanied by a batch-specific Certificate of Analysis (HPLC assay), Material Safety Data Sheet (MSDS), Technical Data Sheet (TDS), Flow Chart of Extraction, Non-GMO Statement, BSE/TSE-Free Certificate, Residual Solvent Test Report (GC-HS), and Heavy Metal/Pesticide Panel reports verified by third-party testing labs (SGS/Eurofins upon request).
Our standard Minimum Order Quantity (MOQ) for bulk Silybin powder is 1 kg for trial/laboratory batches, and 25 kg (1 full fiber drum) for commercial orders. In-stock products ship within 3–5 working days. Air freight to Montevideo (MVD) takes 5 to 7 days, while sea freight arrives at Montevideo Port in 30 to 40 days.
All Silybin powder is packed inside double-layer pharmaceutical-grade polyethylene food bags, heat-sealed with desiccant pouches, and encased in heavy-duty fiber drums. This multi-layer moisture barrier guards against atmospheric humidity, temperature shifts, and light exposure during ocean freight across equatorial trade routes.
Yes. We offer specialized Silybin Phospholipid complexes (Silybin complexed with non-GMO sunflower or soy phosphatidylcholine at a 1:2 or 1:3 ratio). This molecular complex increases Silybin's lipophilic solubility, improving systemic absorption and bioavailability up to 5-10 fold compared to uncomplexed Silybin powder.
Request batch-specific Certificates of Analysis, technical specification dossiers, or 10–20g free samples for laboratory evaluation. Our technical export team responds within 12 hours.