Direct factory supply of bio-active flavonoids, supercritical oleoresins, and liposomal phytosome carriers. Fully compliant with EU Pharmacopoeia, EFSA limits, and regional Greek EOF safety standardizations.
The global botanical extract sector is undergoing a structural transition toward solvent-free, highly selective extraction methodologies. For commercial procurement teams in Greece and the broader Southeastern European region, Supercritical Fluid Extraction (SFE-CO2) represents the gold standard for preserving lipophilic bioactive molecules, thermolabile bioflavonoids, and volatile terpenes without thermal degradation or toxic organic solvent carryover.
At RAAG Biotech Co., Ltd., our engineering infrastructure utilizes dense-phase carbon dioxide operating above its critical point (31.1°C and 73.8 bar). In this state, CO2 exhibits liquid-like density and solvent power combined with gas-like diffusivity and low viscosity. This allows for hyper-efficient mass transfer across plant cellular matrices, isolating active phytocompounds such as quercetin polyphenols, gromwell root shikonins, and essential oleoresins while excluding unwanted heavy metals, high-molecular waxes, and polar contaminants.
| Parameter / Feature | Supercritical CO2 Extraction | Ethanol Reflux Extraction | Water Hydro-Distillation |
|---|---|---|---|
| Operating Temperature | 32°C – 45°C (Low Thermal Stress) | 75°C – 85°C (Moderate Heat Risk) | 100°C (High Thermal Degradation) |
| Solvent Residue (EO Directives) | 0 ppm (Completely Solvent-Free) | Requires Evaporation (<50 ppm) | 0 ppm (Aqueous) |
| Selective Fractionation | Precision Pressure/Temp Tuning | Broad/Non-selective Polarity | Only Steam-Volatile Fractions |
| Preservation of Active Flavonoids | >98% Structural Integrity | 90% – 93% Retention | Degrades Heat-Sensitive Compounds |
| Environmental & Clean-Label Status | 100% Green / Zero VOC Emissions | Requires Solvent Recovery Units | Eco-Friendly / High Energy Usage |
By engineering multi-stage separation vessels within our SFE cascade systems, we can fractionate target compounds by molecular weight and solubility parameters in a continuous run. This technical capability ensures that Greek manufacturing partners receive standardized, batch-consistent ingredients custom-tailored for pharmaceutical formulations, functional dietary gels, and dermatological anti-aging emulsions.
Low-temperature processing preserves heat-sensitive quercetin glycosides and volatile bio-actives without oxidization.
Full batch analytical files including HPLC assay curves, heavy metal ICP-MS, and pesticide screening matching Regulation (EC) 396/2005.
Liposomal and phospholipid matrix encapsulation technologies delivering up to 4.5 times greater human bio-absorption.
Greece serves as a pivotal hub for nutraceutical expansion, cosmeceutical innovation, and Mediterranean functional food production within the European Union. Greek manufacturers operate under rigorous national guidelines enforced by the National Organization for Medicines (EOF - Εθνικός Οργανισμός Φαρμάκων) alongside overarching European Food Safety Authority (EFSA) regulations. The integration of high-purity quercetin powders and SFE supercritical extracts satisfies specific localized formulation demands across multiple industrial verticals:
The Greek dietary supplement sector emphasizes products inspired by Mediterranean longevity diets, combining local botanicals (such as olive polyphenols, wild oregano, and mountain tea) with high-potency standardized flavonoid actives. Quercetin (specifically Sophora Japonica derived 95% and 98% HPLC purity grades) is widely utilized by contract manufacturers in Attica and Thessaloniki to formulate immune-modulating, cardioprotective, and anti-inflammatory capsule products.
Formulating with our Liposomal Quercetin 50% Powder resolves the historically low oral bioavailability of native quercetin crystals. By surrounding raw quercetin with a sunflower-derived phosphatidylcholine bilayer, Greek supplement brands can create fast-acting formulations that pass gastrointestinal transit intact, presenting quantifiable efficacy to wellness-conscious consumers across Athens, Crete, and international export channels.
Greece possesses a globally renowned natural cosmetics industry centered on botanical ingredients, olive oil derivatives, and marine extracts. Formulators in high-end skincare brands require active raw materials that fight UV-induced photoaging, oxidative cell stress, and environmental skin barrier compromise.
Supercritical CO2 extracted oleoresins—such as Gromwell Root SFE Extract and pure Quercetin Anhydrous—provide potent antioxidant profiles. Quercetin inhibits collagenase breakdown and downregulates pro-inflammatory cytokines induced by solar radiation. SFE extraction guarantees that no residual organic solvents (such as hexane or methanol) enter sensitive facial serums or dermo-cosmetic creams, allowing Greek brands to proudly claim clean-label status under EU Cosmetic Regulation (EC) No 1223/2009.
Greece is the world's third-largest producer of extra virgin olive oil (EVOO). A growing trend among Greek food technology institutes involves enriching high-polyphenol olive oils and functional Mediterranean beverages with fat-soluble bio-actives. Supercritical extracts integrate seamlessly into lipid carriers without altering sensory flavor profiles or creating sediment. SFE-extracted quercetin and plant actives act as natural lipophilic stabilizers, inhibiting lipid peroxidation and extending product shelf-life while enabling EFSA-supported antioxidant claims.
Greek pharmaceutical laboratories developing venotonic and vascular resistance medications rely on high-grade Sophora Japonica extracts. Quercetin Dihydrate and Rutin derivatives are recognized for reducing capillary fragility and strengthening vascular endothelium. Our pharmaceutical-grade Quercetin 98% Anhydrous meets strict British and European Pharmacopoeia (Ph. Eur.) standards, making it an ideal bulk active pharmaceutical ingredient (API) intermediate for tablet compression and hard-shell gelatin encapsulation.
Navigating the Southeast European chemical and nutritional raw material market requires detailed alignment with evolving regulatory and consumer frameworks. B2B buyers in Greece face stringent compliance checks at ports of entry such as Piraeus and Thessaloniki. Partnering with a fully certified manufacturer eliminates regulatory friction through rigorous quality assurance infrastructure.
Under EU Regulation (EC) No 396/2005, maximum residue levels (MRLs) for hundreds of agricultural pesticides are continuously updated. Standard solvent extracts sourced from unverified producers often fail European customs testing due to trace organochlorine or ethylene oxide (EtO) contamination. RAAG Biotech enforces end-to-end trace testing: raw Sophora Japonica flower buds undergo comprehensive GC-MS/MS and LC-MS/MS screening covering over 400 pesticide residues, ensuring strict compliance prior to extraction.
Greek consumers are increasingly analytical regarding supplement ingredients, seeking products free from synthetic binders, artificial colors, and chemical extraction residues. SFE-CO2 technology directly fulfills this demand. Because supercritical CO2 depressurizes into a harmless gas upon collection, the resulting extract is pristine, 100% natural, and intrinsically clean-label—granting Greek brands a distinct marketing edge in premium pharmacy channels.
In alignment with Google's Search Quality Rater Guidelines for "Your Money or Your Life" (YMYL) health categories, commercial buyers must verify the Experience, Expertise, Authoritativeness, and Trustworthiness (E-E-A-T) of their supply source. RAAG Biotech maintains fully documented batch traceability: every drum of Quercetin or Horsetail Extract is paired with an audit-ready dossier containing:
Established in 2014, RAAG Biotech Co., Ltd. has developed into a premier botanical extract manufacturer, serving over 300 industrial B2B partners across Europe, North America, and Asia. Our production base in Xi'an, Shaanxi Province spans advanced analytical laboratories, pilot-scale testing facilities, and industrial-scale SFE-CO2 and solvent reflux extraction lines.
State-of-the-art continuous extraction infrastructure handling bulk volume orders with short lead times.
GMP-audited manufacturing plant certified under ISO9001, ISO22000, HALAL, KOSHER, and EU Organic standards.
8+ Senior PhD phytochemists operating Agilent HPLC, GC-MS, and UV-Vis spectrophotometer systems for lot verification.
We do not operate as an intermediary trading enterprise; we are direct primary processors. When Greek procurement managers partner with RAAG Biotech, they gain direct access to our technical engineering team to customize particle size distribution (granulated vs micro-milled 200 mesh), control bulk density, adjust carrier excipients (such as maltodextrin or organic acacia gum), and specify custom marker concentrations.
For in-stock standard items (such as Quercetin 95% Powder or Quercetin Dihydrate), orders are dispatched within 3 to 5 business days. Express air freight to Athens (ATH) or Thessaloniki (SKG) airports takes 5–7 days. Full container loads (FCL) or LCL ocean shipments destined for the Port of Piraeus typically arrive within 22–28 days. All shipments include complete EU export customs documentation.
Sophora Japonica derived Quercetin has a established history of consumption in dietary supplements within the European Union and is not classified as a Novel Food requiring complex EFSA registration, provided purity and marker thresholds are met. We provide complete technical dossiers proving botanical origin, traditional use data, and compliance with EOF notification standards for finished dietary products.
Our standard MOQ for commercial standardized extract powders is 1 kg. For high-purity monomer reference standards or specialized supercritical CO2 oleoresins, our MOQ starts at 100 grams. We supply free 10g to 50g sample packs accompanied by lot-specific COAs for laboratory verification prior to commercial commitment.
Yes. Raw quercetin powder often exhibits poor flowability and static charge. We supply DC-grade (Direct Compression) Quercetin Granular formulations with optimized bulk density and particle size distribution. This enables high-speed tablet pressing without cap formation or machine clogging in Greek pharmaceutical facilities.
Ethylene Oxide (EtO) sterilization is strictly prohibited across all our processing facilities. Micro-biological control is achieved via gentle heat treatment or gamma irradiation upon client request. Every batch is tested via ICP-MS to guarantee Heavy Metals meet stringent EU limits: Lead (Pb) < 3.0 mg/kg, Cadmium (Cd) < 1.0 mg/kg, Mercury (Hg) < 0.1 mg/kg, and Arsenic (As) < 1.0 mg/kg.
Connect with our phytochemistry engineering desk to discuss target assays, customized mesh sizes, SFE parameters, and regional Greek logistics support.